Antidepressants

With the exception of duloxetine, there is not enough reliable evidence to support the use of most antidepressant medications in the relief of chronic pain, a new review and meta-analysis has shown.

Older adults with severe depression have better outcomes when the antipsychotic aripiprazole (Abilify) is added to their existing antidepressant prescription versus a switch to bupropion, a new study has...

There was little to no evidence that tricyclic antidepressants such as amitriptyline were effective in this meta-analysis. Yet drugs in this class are among those most commonly used to treat pain, the...

There is no evidence that serotonin is responsible for depression, raising questions about a basis for the widespread use of antidepressant drugs, say the authors of a major review of published research.

Fewer residents with dementia now receive off-label antipsychotic drugs in VA nursing facilities. But overreliance on other behavior-modifying medications has spiked, a new study finds.

About one fifth of the patients aged 65 and older with first-time depression did not respond to antidepressant treatment during a one-year study period.

Older patients should be temporarily weaned off these drugs whenever possible — well before their scheduled surgery, the researchers say.

Outpatient treatment with the commonly available drug fluvoxamine (Luvox) compares favorably with more expensive treatments such as monoclonal antibodies, investigators say.

Wards with trained nurses showed a significant reduction in psychotropic drug use and drug costs. Maintenance strategies may be needed, however, as the improvements had waned by 12 months, researchers...

Regular versus poor antidepressant use tied to lower risk for advanced diabetic complications, mortality in patients with depression and diabetes