Severe apathy — a lack of interest and loss of desire to participate in daily activities — is tied to greater odds of developing dementia, a nine-year study has found.

At year six, investigators evaluated over 2,000 participants in the Health, Aging, and Body Composition study for self-reported symptoms of apathy, distinguished from depression and anxiety. Volunteers were then grouped according to level of apathy. 

Over the  nine-year study period, dementia developed in 381 participants. Findings, which appeared in Neurology, were adjusted for demographics, cardiovascular risk, genetic risk and depressed mood.