Researchers make 'stunning' Alzheimer's breakthrough, return affected neurons to normal state
Researchers at the Max Planck Florida Institute for Neuroscience may have discovered how the peptide Amyloid beta creates the cognitive dysfunction associated with Alzheimer's disease. The peptide triggers increased levels of a signaling protein, CentA1, and this protein appears to create the disturbances, the researchers found.
The researchers silenced RNA as a way to reduce the production of CentA1 in rat brain samples. When they did, they discovered affected neurons returned to “normal morphology and synaptic function,” even though Amyloid beta was still present.