Potential Alzheimer's treatment discredited
Amyloid inhibitors, once considered the secret to preventing Alzheimer's, have been found to be ineffective in the treatment or prevention of Alzheimer's, a new study has found. And according to Brian Shoichet, senior study author and chemist at the University of California, San Francisco, researchers experimenting with amyloid inhibitors "should stop."
Previous research has found that, in Alzheimer's disease, proteins like amyloid-beta stick together in the brain tissue. It had been thought that amyloid inhibitors would prevent this buildup of proteins. Researchers at UCSF, however, have found that the so-called inhibitors actually form large clumps themselves, making them ineffective tools in treatment or prevention of the disease.
The study was published Jan. 27 in Nature Chemical Biology, a monthly research journal.