Experimental Alzheimer's drug fails to deliver in closely watched clinical trial

Share this article:

Alzheimer's researchers met with disappointment Monday when officials from Pfizer announced that the experimental drug bapineuzumab failed to improve dementia symptoms in a Phase 3 trial.

Lead investigator Reisa Sperling, M.D., told the New York Times that the experimental drug showed “no evidence at all of a clinical benefit of treatment on either of the primary measures, one cognitive and one functional,” compared to placebo. Three drug makers were jointly developing bapineuzumab: Pfizer, Elan and Johnson & Johnson

Scientists told the paper that bapineuzumab's failure, in addition to other recent drug failures, has raised doubts about whether beta- amyloid plaques — proteins in the brain that have been targeted by drug developers — are implicated in the progressive disease.

Earlier trials suggested that bapineuzumab is more successful in Alzheimer's patients a specific gene, called ApoE4, which raises the risk a person will get Alzheimer's disease and can make the disease worse. Trial results testing bapineuzumab in this population will conclude within the next couple months, according to the paper.

Share this article:

More in News

Breier named new CEO at Kindred

Breier named new CEO at Kindred

Kindred Healthcare announced Thursday that it has chosen a new top executive to lead its push toward creating a mammoth national brand. Benjamin A. Breier, the company's current president and ...

Proposed managed care rule could accelerate shift away from nursing home care, official suggests

Proposed managed care rule could accelerate shift away ...

Proposed regulations slated for early 2015 likely will affect how Medicaid managed care balances home- versus facility-based long-term care, news sources reported Wednesday.

Assisted living residents say 'homelike' setting not so important

Contrary to conventional wisdom, assisted living residents might not place a high value on how "homelike" their surroundings are, suggest findings out of St. Catherine University in St. Paul, MN.