Experimental Alzheimer's drug fails to deliver in closely watched clinical trial

Share this article:

Alzheimer's researchers met with disappointment Monday when officials from Pfizer announced that the experimental drug bapineuzumab failed to improve dementia symptoms in a Phase 3 trial.

Lead investigator Reisa Sperling, M.D., told the New York Times that the experimental drug showed “no evidence at all of a clinical benefit of treatment on either of the primary measures, one cognitive and one functional,” compared to placebo. Three drug makers were jointly developing bapineuzumab: Pfizer, Elan and Johnson & Johnson

Scientists told the paper that bapineuzumab's failure, in addition to other recent drug failures, has raised doubts about whether beta- amyloid plaques — proteins in the brain that have been targeted by drug developers — are implicated in the progressive disease.

Earlier trials suggested that bapineuzumab is more successful in Alzheimer's patients a specific gene, called ApoE4, which raises the risk a person will get Alzheimer's disease and can make the disease worse. Trial results testing bapineuzumab in this population will conclude within the next couple months, according to the paper.

Share this article:

More in News

House leader urges HHS to end settlements meant to cut Medicare backlog

The Department of Health and Human Services may not have had the authority to offer providers special settlements to help clear a huge backlog of Medicare appeals, a leading Congressman said in a recent letter to the agency. Rep. Kevin Brady (R-TX) is urging HHS ...

One-fifth of caregivers take 6 months or longer to choose a senior ...

A significant number of people take six months or longer to choose a senior care or housing option for a loved one, recently released survey results showed.

CMS releases updated Minimum Data Set manual

CMS releases updated Minimum Data Set manual

The Centers for Medicare & Medicaid Services released an updated version of the Minimum Data Set 3.0 Resident Assessment Instrument manual Friday.