Common antipsychotics dangerous for older adults, new study says

Share this article:
Common antipsychotics dangerous for older adults, new study says
Common antipsychotics dangerous for older adults, new study says

Adding to the concerns about off-label use of antipsychotics, a new study has found four of the most common medications lack safety and effectiveness in older adults.

Researchers at the University of California, San Diego School of Medicine, Stanford University and the University of Iowa examined aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and risperidone (Risperdal) in 332 patients over five years who had diagnosis associated with schizophrenia, mood disorders, post-traumatic stress disorder or dementia.

They found that a third of the patients developed metabolic syndrome within a year, and a fourth developed serious adverse effects after two years.

"While there were a few significant differences among the four drugs, the overall risk-benefit ratio for the AAPs in patients over age 40 was not favorable, irrespective of diagnosis and drug," said Dilip V. Jeste, M.D., director of the Stein Institute for Research on Aging at UC San Diego.

Results were published in Tuesday's edition of The Journal of Clinical Psychiatry.

Share this article:

More in News

Hospitals in the Midwest refer patients to the broadest networks of skilled nursing facilities, study finds

Hospitals in the Midwest refer patients to the ...

Midwestern hospitals spread referrals to the greatest variety of skilled nursing facilities and tap their favorite SNFs least often, according to a recently published analysis of nationwide referral patterns.

Bill would affect pay, scheduling for some nursing home housekeeping staff

Nursing homes could face more stringent scheduling requirements for housekeeping workers and might be on the hook to compensate them for last-minute shift changes under a bill proposed in both houses of Congress.

Joint Commission adds memory care accreditation

New memory care accreditation for nursing homes encourages staff to use a flexible, problem-solving approach to care for those with dementia, according to Joint Commission guidelines.