Common antipsychotics dangerous for older adults, new study says

Share this article:
Common antipsychotics dangerous for older adults, new study says
Common antipsychotics dangerous for older adults, new study says

Adding to the concerns about off-label use of antipsychotics, a new study has found four of the most common medications lack safety and effectiveness in older adults.

Researchers at the University of California, San Diego School of Medicine, Stanford University and the University of Iowa examined aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and risperidone (Risperdal) in 332 patients over five years who had diagnosis associated with schizophrenia, mood disorders, post-traumatic stress disorder or dementia.

They found that a third of the patients developed metabolic syndrome within a year, and a fourth developed serious adverse effects after two years.

"While there were a few significant differences among the four drugs, the overall risk-benefit ratio for the AAPs in patients over age 40 was not favorable, irrespective of diagnosis and drug," said Dilip V. Jeste, M.D., director of the Stein Institute for Research on Aging at UC San Diego.

Results were published in Tuesday's edition of The Journal of Clinical Psychiatry.

Share this article:

More in News

Septicemia, urinary tract infections rank high on latest list of hospital readmissions causes

Septicemia, urinary tract infections rank high on latest ...

Two infectious conditions common in long-term care settings — septicemia and urinary tract infections — were among the top causes of hospital readmissions for Medicare beneficiaries in 2011, according to ...

PharMerica to pay $200,000 settlement over federal charges of unsafe dispensing practices

Long-term care pharmacy company PharMerica has agreed to pay about $213,000 to settle charges that it dispensed medications without prescriptions and committed other breaches of the Controlled Substances Act, federal authorities announced Wednesday.

Shortchanging the Older Americans Act has led to unnecessary nursing home placements, ...

Chronic underfunding of the Older Americans Act is leading to unnecessary long-term care facility admissions, Sen. Bernard Sanders (I-VT) and 26 of his Democratic colleagues in the Senate said in a recent letter to Appropriations Committee leaders.