Stroke is the third leading cause of death in the U.S. It is also a leading cause of serious, long-term disability and is expected to cost $68.9 billion in direct and indirect costs in the U. S. in 2009. Atrial Fibrillation (AF), a cardiac disorder characterized by cardiac arrhythmia and the absence of coordinated contractions, increases the risk for blood stasis, clot formation, and embolic stroke. This enduring CME activity is designed to provide up-to-date information and guidelines for the prevention of stroke in patients with atrial fibrillation. The program has been designed to provide a balance of expert-driven and learner-directed education.